European Projects

We invest in long-term innovation and have set up various platforms to focus on several fields of innovation with our technology:

  • Biosurgery
  • Viscosupplementation
  • Drug Delivery System

At KitoZyme, we also develop European projects such as:

  • Starting of the European project REBORNE aiming at bone defects regeneration using stem cells and biomaterials in 5 multi-centre clinical trials.

    Submitted by the end of 2008, the project REBORNE for ‘Regenerating Bone defects using New biomedical Engineering approaches’ has been accepted by the European Commission in the thematic area Health of the 7th Framework Program. Coordinated by Inserm, this large scale integrated project has started in January 2010 with a budget of 12 millions € over 5 years. Bone is the most frequently transplanted human tissue with about one million procedures annually in Europe. Either autologous or allogeneic bone grafts are primary used by orthopedic or maxillofacial surgeons to reconstruct large bone defects. However, these bone grafts have drawbacks such as a second surgical site with complications, limited quantity and possible immunological reactions. Human mesenchymal stem cells from bone marrow or adipose tissue have a great potential for bone regeneration. Significant growth opportunities exist for synthetic biomaterials in association with mesenchymal stem cells as bone tissue engineered substitutes. The objectives of REBORNE is to perform multi-centre clinical trials using advanced biomaterials and cells from autologous or allogeneicsources. Five clinical trials in orthopedic and maxillofacial surgery will take place in 12 clinical centers spread over 8 European countries. A large consortium of 24 participants with top world class laboratories, SMEs manufacturing biomaterials, GMP- cells producing facilities and hospitals will collaborate to reach these ambitious clinical targets.

    During the REBORNE project, KitoZyme will develop and characterize hydrogels to be used as advanced biomaterials for bone repair. After a screening of the in vitro and in vivo properties, one type of hydrogel will be selected and KitoZyme will scale-up the process in the GMP facility. Clinical trials for the repair of non-mechanically stressed bone defects will be finally performed withthis material.

    Keen to know more about this project? If so, contact us

    • A pilot line of antibacterial and antifungal medical textiles based on a sonochemical process

      SONO Project:
      Objectives

      Hospital-acquired (nosocomial) infections are a major financial issue in the European healthcare system. The financial impact of these infections counteract medical advances and expensive medical treatments by increasing the length of hospital stay by at least 8 days on average per affected patient, hence adding more than 10 millions patient days in hospitals in Europe per year. The statistics on patient safety in the EU show alarming tendencies : - 1 in 10 patients are affected by hospital-acquired infections - 3 million deaths are caused by hospital-acquired infections An active infection control program of patients and personnel and hygiene measures, have proven to significantly reduce both the number of infections and hospitalisation costs . The SONO project directly addresses the above problems by developing a pilot line for the production of medical antibacterial textiles. The pilot line will be based on the scale-up of a sonochemical process developed and patented at BIU laboratories. The pilot line will use a sonochemical technique to produce and deposit inorganic, antimicrobial nanoparticles on medical textiles, e.g. hospital sheets, medical coats and bandages. Sonicators are used industrially for heavy and light duty cleaning, for water disinfection and for sewage treatment. It is also used in the food industry for emulsification and drying. The proposed concept based on one step sonochemical process to produce nanoparticles and impregnate them as antibacterial factors on textile is novel and does not exist on an industrial scale. The concept has already been proven (and patented) on a lab scale where sonochemistry was applied to impregnate nanoparticles in a single-step process. It was demonstrated that due to the special properties of the sonochemical method the antibacterial nanoparticles are adsorbed permanently on the fibres even after 70 “laundry cycles”. The sonochemical impregnation process is a one-step procedure in which the nanoparticles are produced and impregnated into the textile.

      KitoZyme will provide chitosan and chitosan derivates for embedment of antimicrobial compounds onttextiles through sonochemistry.

      Keen to know more about this project? If so, contact us

        Beginning: 01 October 2009 / End: 30 September 2013
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